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Synthesis of Polycyclic Benzofused Nitrogen Heterocycles via a Tandem Benzannulation/Ring-Closing Metathesis Strategy. Application in a Formal Synthesis of (+)-

机译：通过串联苯并环化/闭环复分解策略合成多环苯并氮杂环化合物。在（+）的形式合成中的应用 -

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A two-stage “tandem strategy” for the synthesis of benzofused nitrogen heterocycles is described that is particularly useful for the construction of systems with a high level of substitution on the benzenoid ring. The first stage in the strategy involves abenzannulation based on the reaction of cyclobutenones with ynamides. This cascade process proceeds via a sequence of four pericyclic reactions and furnishes a multiply substituted aniline derivative which can bear a variety of functionalized substituents at the position ortho to the nitrogen. In the second stage of the tandem strategy, ringclosing metathesis generates the nitrogen heterocyclic ring. This two-step sequence provides efficient access to highly substituted dihydroquinolines, benzazepines, benzazocines, and related benzofused nitrogen heterocyclic systems. The application of this chemistry in a concise formal total synthesis of the anticancer agents (þ)-FR900482 and (þ)-FR66979 is described.

机译：描述了用于合成苯并稠合氮杂环的两阶段“串联策略”，该方法对于构建在苯环上具有高取代度的体系特别有用。该策略的第一阶段涉及基于环丁烯酮与酰胺的反应的苯并氮杂化。该级联过程通过四个周环反应的顺序进行，并提供了一个多取代的苯胺衍生物，该衍生物可以在氮的邻位带有各种官能化的取代基。在串联策略的第二阶段，闭环复分解生成氮杂环。这两个步骤的序列可有效访问高度取代的二氢喹啉，苯并ze庚因，苯并偶氮辛和相关的苯并稠合氮杂环系统。描述了该化学方法在简明的正式全合成抗癌剂（I）-FR900482和（I）-FR66979中的应用。

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Mak, Xiao Yin; Crombie, Aimee L.; Danheiser, Rick Lane;
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年度 2011
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1. Synthesis of Polycyclic Benzofused Nitrogen Heterocycles via a Tandem Ynamide Benzannulation/Ring-Closing Metathesis Strategy. Application in a Formal Total Synthesis of (+)-FR900482 [J] . Mak Xiao Yin, Crombie Aimee L., Danheiser Rick L. The Journal of Organic Chemistry . 2011,第6期

机译：通过串联亚酰胺苯环/环封闭复分解策略合成多环苯并氮杂环。在（+）-FR900482形式的全合成中的应用
2. An efficient synthesis of nitrogen-containing heterocycles via a tandem carbenoid N-H insertion/ring-closing metathesis sequence [J] . Oksana Pavlyuk, Henrik Teller, Mark C. McMills Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2009,第23期

机译：通过串联类胡萝卜素N-H插入/闭合环置换序列有效合成含氮杂环
3. Application of Tandem Ring-Closing Enyne Metathesis: Formal Total Synthesis of (-)-Cochleamycin A [J] . Mukherjee S, Lee D Organic letters . 2009,第13期

机译：串联闭合环烯炔复分解的应用：（-）-环霉素A的正式全合成
4. Parallel Solid-Phase Synthesis of Macrocyclic Peptidomimetics Using Ru-Catalyzed Ring-Closing Metathesis and a New Application of Cross Metathesis [C] . Sylvie Beaubien, Hamid R. Hoveyda, Martin Vezina American Peptide Symposium . 2009

机译：用Ru催化的闭环复分解和交叉复分解的新应用，平行固相合成大环肽肽剂及新应用
5. Synthesis of Nitrogen-Containing Heterocycles via Carbenoid Insertion/Ring-Closing Metathesis Sequence [D] . Pavlyuk, Oksana M. 2011

机译：通过类胡萝卜素插入/封闭环复分解序列合成含氮杂环
6. Synthesis of Polycyclic Benzofused Nitrogen Heterocycles via a Tandem Ynamide Benzannulation/Ring Closing Metathesis Strategy. Application in a Formal Total Synthesis of (+)-FR900482 [O] . Xiao Yin Mak, Aimee L. Crombie, Rick L. Danheiser -1

机译：经由串联炔酰胺苯并环化/环多环苯并稠氮合成杂环闭合置换策略。在正式的全合成（+）应用 - FR900482
7. Low Catalyst Loadings in Olefin Metathesis: Synthesis of Nitrogen Heterocycles by Ring-Closing Metathesis [O] . Kuhn Kevin M., Champagne Timothy M., Hong Soon Hyeok, 2010

机译：烯烃复分解中的低催化剂负载量：通过闭环复分解合成氮杂环

Synthesis of Polycyclic Benzofused Nitrogen Heterocycles via a Tandem Benzannulation/Ring-Closing Metathesis Strategy. Application in a Formal Synthesis of (+)-

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